Endowment for Medical Research - FREE Education - Glycomics - Brain Function

Easy Find It Page

Use Our Mobile Site

Share This Website
Share

The Sugar Trehalose
Read about Trehalose Read Trehalose Label Order Trehalose Now Order T/C+ Now Trehalose FAQ pH Fusion Tea™ with Trehalose

Free NEWS Letter
Stay Up To Date - Subscribe Now

Affiliate Program
Untitled Document Already an Affiliate? Click on the link below to access your account-

Endowment Book Store
Books, DVDs, CDs, Publications

The Trehalose Store
All Trehalose Products

Endowment Store Front
Your Resource Area

Support The Endowment
Enter Amount: $

We Accept

Download Store
Download 7 Free Newsletters Plus Other Educational Materials

Main Menu

Home

- - - - - - -

Inside the Human Cell

The Sugar Trehalose

- - - - - - -

Sugar Science Forum

Glycomics Training

Interactive Glycomics Brochure

NEWS

HOT Links of Interest

- - - - - - -

Disclaimer

Sitemap

Read about Trehalose

Order Trehalose Now

Educational e-textbook
Chapter One FREE Sneek Peek Chapter One

Educational e-textbook

Chapter One

FREE Sneek Peek
Chapter One

Evaluation Forms
Huntington’s General Health Evaluation FORM for Trehalose Nutritional Pilot Survey Parkinson's General Health Evaluation FORM for Trehalose Nutritional Pilot Survey Alzheimer / Dementia General Health Evaluation FORM for Trehalose Nutritional Pilot Survey Diabetic Health Evaluation FORM for Trehalose Nutritional Pilot Survey General Public Health Evaluation FORM for Trehalose Nutritional Pilot Survey (For General Public without Huntington’s, Alzheimer’s, or Parkinson’s.)

Evaluation Forms

Huntington’s General
Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

Parkinson's General
Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

Alzheimer / Dementia
General Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

Diabetic Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

General Public Health
Evaluation FORM for
Trehalose Nutritional
Pilot Survey (For General
Public without Huntington’s,
Alzheimer’s, or Parkinson’s.)

Who's Online
We have 127 guests online

Search This Site

To Kill A Rat Paperback
Hot Off the Press Purchase 1 copy Quantity Discount Buy 10 Save Big To Kill A Rat E-book

To Kill A Rat Paperback

Hot Off the Press

Purchase 1 copy

Quantity Discount
Buy 10 Save Big

To Kill A Rat E-book

Choose a Pilot Survey
Matched Funding See if you qualify Learn More Now!

My Gift Book for You!
Change Your Sugar, Change Your Life! - Free Download Available only at DiabeticHope.com

My Gift Book for You!

Change Your Sugar, Change Your Life! - Free Download

Available only at
DiabeticHope.com

Sugar Science E-book
Find Out More! This easy to read entertaining science book references over 700 MDs, PhDs, Scientists, Researchers and Educators in the field of Glycomics and Brain Function. Read why you will want this e-textbook today

Glycomics Training
Glycomics Training General Public DVD Series

Sugar Science Forum
Two Texas Enemies Died years apart. This is the untold story Former Texas Governor Mark White and Radio Preacher Lester Roloff “Radio preacher… Patricia Champion - 1st Participant GlycoScience Institute Memorial Scholarship Patricia Ann Champion - February 11, 1945 - March 31, 2016 First… Let’s Improve the Brain Safely & Naturally Without Drugs- Glycoscience Lesson #5 Every brain is eligible for improvement and this may be that for which… Breeding Better Fruits and Vegetables - GMO Alternative - Glycoscience Lesson #4 Blending of old world experience and ultrahigh technology by JC Spencer Early Diagnoses of Cognitive Problems - Glycoscience #3 Memory loss and ability for instant recall is a growing challenge for many.

Sugar Science Forum

Two Texas Enemies Died years apart. This is the untold story
Former Texas Governor Mark White and Radio Preacher Lester Roloff

“Radio preacher…
Patricia Champion - 1st Participant GlycoScience Institute Memorial Scholarship
Patricia Ann Champion - February 11, 1945 - March 31, 2016

First…
Let’s Improve the Brain Safely & Naturally Without Drugs- Glycoscience Lesson #5
Every brain is eligible for improvement and this may be that for which…
Breeding Better Fruits and Vegetables - GMO Alternative - Glycoscience Lesson #4
Blending of old world experience and ultrahigh technology

by JC Spencer
Early Diagnoses of Cognitive Problems - Glycoscience #3
Memory loss and ability for instant recall is a growing challenge for many.

Share With a Friend

Inside The Human Cell
Inside The Human Cell Understand better the inner working of your cells and the role glycomics plays in keeping your cells healthy. This booklet is a project of National Institute of Health. The glycomics information is highlighted in yellow.

Inside The Human Cell

Understand better the inner working of your cells and the role glycomics plays in keeping your cells healthy.

This booklet is a project of National Institute of Health. The glycomics information is highlighted in yellow.

Doctors Library
For Doctors Only

Training Available
Our Plan for Lowering Healthcare Costs for Families, Companies, and the Nation! A MUST READ

Popular
Breastfeeding Lowers Mother's Risk of Diabetes A Guide To Our News Sections The Official Affiliate Site for Jack Kettler Trehalose Heart Attack Risk Increase Linked to Noise

Meet J.C. Spencer
"Glycomics II" Replay 30 minute Conference call from July 3rd, 2008 "Glycomics" Replay 30 minute Conference call from June 5th, 2008 "Trehalose and Huntington's Disease" Replay 30 minute Conference call from May 8th, 2008

Really Simple Syndication
Health Bloggers Are Encouraged To Subscribe

New Research Study Explains HOW the Sugar Trehalose Inhibits Alzheimer�s

Comments by J. C. Spencer

Over the last few years research in Universities around the world have supported evidence that the sugar trehalose inhibits protein plaque buildup that causes neurodegenerative diseases including Alzheimer�s, Parkinson�s, and Huntington�s diseases. A new report from the Tianjin University in China explains just how trehalose is able to accomplish this remarkable event in the brain. We learn that the trehalose molecules cluster around the peptide at a specific distance. The intra-peptide hydrophobic interactions are weakened and the Aβ42 contacts are decreased by the trehalose. This finding shines light on the actual molecular mechanism that has the inhibiting effect. More research is needed. This evidence helps point the way for better mental health and neurodegenerative research.

Here is the Abstract and supporting references.

- - - - - - - - - - - - - - -

Molecular Dynamics Simulation of the Conformational Transition of Amyloid Peptide 42 Inhibited by Trehalose

LIU Fu-Feng, DONG Xiao-Yan, SUN Yan

Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China

Abstract:

The molecular mechanism of the conformational transition of amyloid peptide (Aβ) 42 inhibited by trehalose was studied using molecular dynamics simulations. It is confirmed that the conformational transition of Aβ42 is prevented by trehalose in a dose-dependent manner. In water and low-concentration trehalose (0.18 mol�L-1) solutions, Aβ42 transforms from its initial α-helix to a β-sheet. In 0.37 mol�L-1 trehalose, however, the conformational transition of Aβ42 is prevented. It is obvious that there is a hydration shell within about 0.2 nm from the closest atoms of Aβ42 on the peptide surface, which is caused by the preferential exclusion of trehalose. Trehalose molecules cluster around the peptide at a distance of 0.4 nm. In addition, the intra-peptide hydrophobic interactions are weakened and the number of long range contacts of Aβ42 is decreased by trehalose. Therefore, the hydrophobic collapse of the peptide is alleviated and the conformational transition is inhibited. The work has shed some light on the molecular mechanism of the inhibition effect for the conformational transition of Aβ in the presence of trehalose. These findings are important for the rational design of a highly efficient inhibitor of Alzheimer's disease.

Keywords: Molecular dynamics simulation Alzheimer's disease Amyloid peptide Trehalose Received: 2009-12-10 Accepted: 2010-03-03 Online: 2010-04-23 Corresponding Authors: SUN Yan Email: [email protected]

Hot Off the Press

Purchase 1 copy

Quantity Discount Buy 10 Save Big

To Kill A Rat E-book

Quantity Discount
Buy 10 Save Big